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The Crawford lab uses a comparative neuroscience approach to understand how your sense of touch and your sense of pain are interrelated and how they dysfunction in the face of disease. The diverse morphologic and physiologic feature of sensory neuron subtypes may underlie unique reactions to injury and, thus, unique roles in pathologic conditions.  We aim to identify specific molecules that are altered in our disease models, to determine which sensory neuron subtypes exhibit these changes, and to evaluate this pattern of changes across different disease conditions including nerve injury pain and visceral pain in models of bladder disease. Comparative approaches in the lab evaluate cell-specific changes in molecular markers and microscopic anatomy in sensory tissues from a wide range of other species, including tissue samples from veterinary patients.

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