Basic science writing and presentation skills for PhD students in Biology. Designed for second year graduate students preparing for qualifying exams. In the first half of the course, students will produce weekly writing assignments and critique writing submitted by others. In the second half, students will learn techniques for effective research presentations in both seminar style environments and chalk-talk settings.

Advanced version of BIOL 376: Microbial Diversity and Pathogenesis Lab for graduate students only. Additional readings and course work as directed. Permission of instructor. BIOL 575 previously or concurrently is recommended but not required.

Advanced version of BIOL 375: Microbial Diversity and Pathogenesis for graduate students only. Additional readings and course work as directed.

Mathematical modeling is increasingly becoming a standard technique in physiology and cell biology. In this class, we will cover some classical models in physiology and cell biology. Half of the course will be devoted to electrophysiology (Hodgkin-Huxley model, action potential propagation and related topics), which has arguably been the most successful area of application of mathematical techniques to biology. We will then consider models of molecular motors and muscle mechanics, of pattern formation and cell polarization.

This course will survey the discipline of molecular genetics. Two broad areas will be considered: 1) Molecular biology: DNA replication, transcription, translation, and the regulation of gene expression in both prokaryotic and eukaryotic systems and genomics and 2) Genetics: basic Mendelian & molecular genetics.

This course will survey the discipline of molecular genetics. Two broad areas will be considered: 1) Molecular biology: DNA replication, transcription, translation, and the regulation of gene expression in both prokaryotic and eukaryotic systems and genomics and 2) Genetics: basic Mendelian & molecular genetics.

This course will survey the discipline of molecular genetics. Two broad areas will be considered: 1) Molecular biology: DNA replication, transcription, translation, and the regulation of gene expression in both prokaryotic and eukaryotic systems and genomics and 2) Genetics: basic Mendelian & molecular genetics.

Epigenetic alterations encompass heritable, non-genetic changes to chromatin (the polymer of DNA plus histone proteins) that influence cellular and organismal processes. This course will examine epigenetic mechanisms in directing development from the earliest stages of growth, and in maintaining normal cellular homeostasis during life. We will also explore how diverse epigenetic processes are at the heart of numerous human disease states. We will review topics ranging from an historical perspective of the discovery of epigenetic mechanisms to the use of modern technology and drug development to target epigenetic mechanisms to increase healthy lifespan and combat human disease. The course will involve a combination of didactic lectures, primary scientific literature and research lectures, and student-led presentations. Prerequisite: BIOL 483 recommended

Life depends on the propagation of genetic material from one generation to the next through cycles of genome replication and cell division. The genome is copied by the parent, and one exact copy is inherited by each daughter cell. We will treat chromosomes as discrete entities, rather than collections of genes, that are replicated and divided with high fidelity to ensure that the genome remains stable over many generations. By reading selected primary literature covering several decades, we will build an understanding of the cell cycle by focusing on chromosomes and the associated molecular machinery. We will explore mechanisms that underlie replication and division, particularly control mechanisms that maintain genome integrity and are critical to prevent disease. The goal of the course is to develop a picture of the cell cycle by examining some of the key experiments and insights that have led to our current understanding.

This course is designed for beginning graduate students and advanced undergraduates with a particular enthusiasm for cell biology. Biology 480 does not attempt to cover all aspects of cell biology, and is therefore not appropriate for students seeking a lecture course which provides a comprehensive survey of the field. Rather, the primary objective of this course is to teach those students considering a career in the biomedical sciences how to read, discuss, and question original research papers effectively. Intensive classroom discussions focus on the experimental methods used, results obtained, interpretation of these results in the context of cell structure and function, and implications for further studies. There is no assigned text; students learn to critically evaluate current literature by reading original papers on selected topics in modern cell biology. Accordingly, class participation/discussion is essential and the grade will be determined significantly by that. In addition, there will be two exams including answering short questions and an essay critiquing an original paper that is selected on a topic in Cell Biology.